Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …

Background Excitatory synapses in the CNS are highly dynamic structures that can show
activity-dependent remodeling and stabilization in response to learning and memory …

Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin
and nervous system disorders. In many cases, pathological itch is insensitive to …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially
expressed in the small-diameter primary sensory neurons and involved in the mediation of …

Neurons have long held the spotlight as the central players of the nervous system, but we
must remember that we have equal numbers of astrocytes and neurons in the brain. Are …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

The roles that astrocytes play in the evolution of abnormal network excitability in chronic
neurological disorders involving brain injury, such as acquired epilepsy, are receiving …

Mast cells play a central role in inflammatory and allergic reactions by releasing
inflammatory mediators through two main pathways, immunoglobulin E-dependent and …