Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures
that only occurs under pathological conditions. In the present paper, we summarize the …

Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of
neurons and glial cells across the cortex. SD is thought to contribute to the underlying …

Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure
proper brain function. The adult human brain represents only a small portion of the body …

Clinical studies have revealed a strong link between increased burden of cerebral
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …

Background: Spreading depolarizations (SDs) are believed to contribute to injury
progression and worsen outcomes in focal cerebral ischemia because exogenously induced …

Gaining insights into brain oxygen metabolism has been one of the key areas of research in
neurosciences. Extensive efforts have been devoted to developing approaches capable of …

Extensive in vivo imaging studies investigate the hippocampal neural network function,
mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI …

Secondary injury following acute brain insults significantly contributes to poorer neurological
outcome. The spontaneous, recurrent occurrence of spreading depolarization events (SD) …