The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

A novel syndrome called long-haul COVID or long COVID is increasingly recognized in a
significant percentage of individuals within a few months after infection with SARS-CoV-2 …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …

Pseudomonas aeruginosa is a common cause of pulmonary infection. As a Gram-negative
pathogen, it can initiate a brisk and highly destructive inflammatory response; however, most …

In recent years dietary interventions have become a promising tool in cancer treatment and
have demonstrated a powerful ability to alter metabolism and tumor growth, development …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Background Alzheimer's disease (AD) is the most common neurodegenerative disease.
Mitochondrial dysfunction and immune responses are important factors in the pathogenesis …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …