Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …

Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in
drug delivery and bioimaging. With more characteristics of EVs explored through …

Plasma membrane curvature is an important factor in the regulation of cellular phenotype
and is critical for various cellular activities including the shedding of extracellular vesicles …

Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …

Intercellular communications play a major role in tissue homeostasis. In pathologies such as
cancer, cellular interactions within the tumor microenvironment (TME) contribute to tumor …

Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …

In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes
have emerged as a novel mechanism of intercellular communication. Protrusion-based …

Mitochondria are key regulators of cell survival and are involved in a plethora of
mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) …

Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …