Cell cycle on the crossroad of tumorigenesis and cancer therapy
Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying
tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic …
tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic …
[HTML][HTML] Structural insights into protein regulation by phosphorylation and substrate recognition of protein kinases/phosphatases
SH Seok - Life, 2021 - mdpi.com
Protein phosphorylation is one of the most widely observed and important post-translational
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …
[HTML][HTML] Discovery of pyrazolo [3, 4-d] pyrimidine and pyrazolo [4, 3-e][1, 2, 4] triazolo [1, 5-c] pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and …
IF Nassar, MTA Aal, WA El-Sayed, MAE Shahin… - RSC …, 2022 - pubs.rsc.org
CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …
From structure modification to drug launch: A systematic review of the ongoing development of cyclin-dependent kinase inhibitors for multiple cancer therapy
Z Shi, L Tian, T Qiang, J Li, Y Xing, X Ren… - Journal of medicinal …, 2022 - ACS Publications
Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …
approved or have undergone clinical trials and their therapeutic application in multiple …
[HTML][HTML] Integrative bioinformatics approaches to map potential novel genes and pathways involved in ovarian cancer
Background and aims: Ovarian cancer (OC) is the seventh most commonly detected cancer
among women. This study aimed to map the hub and core genes and potential pathways …
among women. This study aimed to map the hub and core genes and potential pathways …
Prediction of protein-protein interactions based on ensemble residual convolutional neural network
H Gao, C Chen, S Li, C Wang, W Zhou, B Yu - Computers in Biology and …, 2023 - Elsevier
With the development of bio-medical big data, the prediction of protein-protein interactions
(PPIs) with the help of deep learning (DL) has attracted much attention for the study of …
(PPIs) with the help of deep learning (DL) has attracted much attention for the study of …
[HTML][HTML] Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket
have the potential for improved selectivity due to the often observed lower structural …
have the potential for improved selectivity due to the often observed lower structural …
Novel N-bridged pyrazole-1-carbothioamides With Potential Antiproliferative Activity: design, synthesis, In Vitro and In Silico Studies
Thiazole-substituted pyrazole is an important structural feature of many bioactive
compounds, including antiviral, antitubercular, analgesic and anticancer agents. Herein we …
compounds, including antiviral, antitubercular, analgesic and anticancer agents. Herein we …
Development of CDK2 and CDK5 dual degrader TMX‐2172
Abstract Cyclin‐dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment
of cancer. Development of CDK2 inhibitors has been extremely challenging as its ATP …
of cancer. Development of CDK2 inhibitors has been extremely challenging as its ATP …
Pharmacological relevance of CDK inhibitors in Alzheimer's disease
Evidence suggests that cell cycle activation plays a role in the pathophysiology of
neurodegenerative diseases. Alzheimer's disease is a progressive, terminal …
neurodegenerative diseases. Alzheimer's disease is a progressive, terminal …