The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

Scientifically sound, risk-informed evaluation of chemicals is essential to protecting public
health. Systematically leveraging information from exposure, toxicology, and epidemiology …

Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level) …

The convergence of HPC and data intensive methodologies provide a promising approach
to major performance improvements. This paper provides a general description of the …

MRI-based biomechanical studies can provide a deep understanding of the mechanisms
governing liver function, its mechanical performance but also liver diseases. In addition …

Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool with many
demonstrated applications in various phases of drug development and regulatory review …

Idiosyncratic drug-induced liver injury (iDILI) is a serious concern in drug development. The
rarity and multifactorial nature of iDILI makes it difficult to predict and explain. Recently …

Highlights•A variety of computational methods and tools are used in QSP and QST. They
show different degrees of maturity.•PBPK models are well established and applied in a wide …

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility
to liver failure varies across individuals and is influenced by factors such as health status …