[HTML][HTML] Towards organoid culture without Matrigel

MT Kozlowski, CJ Crook, HT Ku - Communications biology, 2021 - nature.com
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

M Brown, J Li, C Moraes, M Tabrizian, NYK Li-Jessen - Biomaterials, 2022 - Elsevier
Extracellular matrix is rich in biomolecules including structural proteins,
glycosaminoglycans, and small molecules that are important for the maintenance and repair …

[HTML][HTML] Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

GG Giobbe, C Crowley, C Luni, S Campinoti… - Nature …, 2019 - nature.com
Organoids have extensive therapeutic potential and are increasingly opening up new
avenues within regenerative medicine. However, their clinical application is greatly limited …

[HTML][HTML] Microtechnology-based methods for organoid models

V Velasco, SA Shariati, R Esfandyarpour - Microsystems & …, 2020 - nature.com
Innovations in biomaterials and stem cell technology have allowed for the emergence of
novel three-dimensional (3D) tissue-like structures known as organoids and spheroids. As a …

[HTML][HTML] Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

Y Wang, RK Kankala, C Ou, A Chen, Z Yang - Bioactive materials, 2022 - Elsevier
The construction of biomimetic vasculatures within the artificial tissue models or organs is
highly required for conveying nutrients, oxygen, and waste products, for improving the …

[HTML][HTML] Research progress in decellularized extracellular matrix-derived hydrogels

W Zhang, A Du, S Liu, M Lv, S Chen - Regenerative therapy, 2021 - Elsevier
Decellularized extracellular matrix (dECM) is widely used in regenerative medicine as a
scaffold material due to its unique biological activity and good biocompatibility. Hydrogel is a …

[HTML][HTML] Promising applications of tumor spheroids and organoids for personalized medicine

Z Gilazieva, A Ponomarev, C Rutland, A Rizvanov… - Cancers, 2020 - mdpi.com
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …

[HTML][HTML] Mechano-modulatory synthetic niches for liver organoid derivation

G Sorrentino, S Rezakhani, E Yildiz, S Nuciforo… - Nature …, 2020 - nature.com
The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …

Decellularized extracellular matrix for remodeling bioengineering organoid's microenvironment

L Zhu, J Yuhan, H Yu, B Zhang, K Huang, L Zhu - Small, 2023 - Wiley Online Library
Over the past decade, stem cell‐and tumor‐derived organoids are the most promising
models in developmental biology and disease modeling, respectively. The matrix is one of …

Engineered biomimetic hydrogels for organoids

Y Li, Q Saiding, Z Wang, W Cui - Progress in Materials Science, 2023 - Elsevier
Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or
adult stem cells cultured under laboratory conditions, emerge as a captivating model and …