The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

Biologics for treatment of atopic dermatitis: current status and future prospect

T Ratchataswan, TM Banzon, JP Thyssen… - The Journal of Allergy …, 2021 - Elsevier
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense
pruritus and recurrent eczematous lesions that significantly impair quality of life. It is a …

Th2/Th1 cytokine imbalance is associated with higher COVID-19 risk mortality

AB Pavel, JW Glickman, JR Michels… - Frontiers in …, 2021 - frontiersin.org
A major component of COVID-19 severe respiratory syndrome is the patient's immune
response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory …

Endophenotypic variations of atopic dermatitis by age, race, and ethnicity

T Nomura, J Wu, K Kabashima… - The Journal of Allergy and …, 2020 - Elsevier
Atopic dermatitis (AD) is a heterogeneous disease with unique clinical manifestations across
age groups and race/ethnicities. Characteristic molecular mechanisms, known as …

Advances in atopic dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune …

T Nomura, K Kabashima - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A
comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent …

Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation

JW Glickman, C Dubin, Y Renert-Yuval… - Journal of the American …, 2021 - Elsevier
Background Although there is increased understanding of the alopecia areata (AA)
pathogenesis based on studies in scalp tissues, little is known about its systemic profile …

EAACI Biologicals Guidelines—dupilumab for children and adults with moderate‐to‐severe atopic dermatitis

I Agache, CA Akdis, M Akdis, K Brockow, T Chivato… - Allergy, 2021 - Wiley Online Library
Atopic dermatitis imposes a significant burden on patients, families and healthcare systems.
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …

Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study

R Bissonnette, J DuBois, P Facheris, E Del Duca… - Allergy, 2024 - Wiley Online Library
Background RPT193 is an orally administered small molecule antagonist of the human C‐C
motif chemokine receptor 4 (CCR4) that inhibits the migration and downstream activation of …

Vascular inflammation in moderate‐to‐severe atopic dermatitis is associated with enhanced Th2 response

AP Villani, AB Pavel, J Wu, M Fernandes, C Maari… - Allergy, 2021 - Wiley Online Library
Background In atopic dermatitis (AD), some studies have shown an association with
increased cardiovascular disease in certain populations. However, other investigations …

Improving evaluation of drugs in atopic dermatitis by combining clinical and molecular measures

JW Glickman, J Han, S Garcet… - The Journal of …, 2020 - jaci-inpractice.org
Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease that affects nearly 10%
of adults worldwide. 1 AD is heterogeneous, predominated by TH2/TH22 activation with …