Automated chemical oligosaccharide synthesis: novel approach to traditional challenges
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …
more accessible. However, many current methods still rely heavily upon specialized …
Advances in glycoside and oligosaccharide synthesis
CJ Crawford, PH Seeberger - Chemical Society Reviews, 2023 - pubs.rsc.org
The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …
“One-pot” protection, glycosylation, and protection–glycosylation strategies of carbohydrates
SS Kulkarni, CC Wang, NM Sabbavarapu… - Chemical …, 2018 - ACS Publications
Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …
significant roles in a variety of vital biological processes. Access to unique and …
Oligosaccharide synthesis and translational innovation
L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
Automated glycan assembly: a perspective
M Guberman, PH Seeberger - Journal of the American Chemical …, 2019 - ACS Publications
The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …
Toward automated enzymatic synthesis of oligosaccharides
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
Automated assembly of starch and glycogen polysaccharides
Polysaccharides are Nature's most abundant biomaterials essential for plant cell wall
construction and energy storage. Seemingly minor structural differences result in entirely …
construction and energy storage. Seemingly minor structural differences result in entirely …
Glycoconjugate vaccines: current approaches towards faster vaccine design
F Micoli, L Del Bino, R Alfini, F Carboni… - Expert review of …, 2019 - Taylor & Francis
Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …
Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions
T Hansen, H Elferink, JMA van Hengst… - Nature …, 2020 - nature.com
Controlling the chemical glycosylation reaction remains the major challenge in the synthesis
of oligosaccharides. Though 1, 2-trans glycosidic linkages can be installed using …
of oligosaccharides. Though 1, 2-trans glycosidic linkages can be installed using …
Remote participation during glycosylation reactions of galactose building blocks: direct evidence from cryogenic vibrational spectroscopy
Abstract The stereoselective formation of 1, 2‐cis‐glycosidic bonds is challenging. However,
1, 2‐cis‐selectivity can be induced by remote participation of C4 or C6 ester groups …
1, 2‐cis‐selectivity can be induced by remote participation of C4 or C6 ester groups …