Automated chemical oligosaccharide synthesis: novel approach to traditional challenges

M Panza, SG Pistorio, KJ Stine… - Chemical reviews, 2018 - ACS Publications
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Advances in glycoside and oligosaccharide synthesis

CJ Crawford, PH Seeberger - Chemical Society Reviews, 2023 - pubs.rsc.org
The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

“One-pot” protection, glycosylation, and protection–glycosylation strategies of carbohydrates

SS Kulkarni, CC Wang, NM Sabbavarapu… - Chemical …, 2018 - ACS Publications
Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

Oligosaccharide synthesis and translational innovation

L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Automated glycan assembly: a perspective

M Guberman, PH Seeberger - Journal of the American Chemical …, 2019 - ACS Publications
The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …

Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Automated assembly of starch and glycogen polysaccharides

Y Zhu, M Delbianco, PH Seeberger - Journal of the American …, 2021 - ACS Publications
Polysaccharides are Nature's most abundant biomaterials essential for plant cell wall
construction and energy storage. Seemingly minor structural differences result in entirely …

Glycoconjugate vaccines: current approaches towards faster vaccine design

F Micoli, L Del Bino, R Alfini, F Carboni… - Expert review of …, 2019 - Taylor & Francis
Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …

Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions

T Hansen, H Elferink, JMA van Hengst… - Nature …, 2020 - nature.com
Controlling the chemical glycosylation reaction remains the major challenge in the synthesis
of oligosaccharides. Though 1, 2-trans glycosidic linkages can be installed using …

Remote participation during glycosylation reactions of galactose building blocks: direct evidence from cryogenic vibrational spectroscopy

M Marianski, E Mucha, K Greis, S Moon… - Angewandte Chemie …, 2020 - Wiley Online Library
Abstract The stereoselective formation of 1, 2‐cis‐glycosidic bonds is challenging. However,
1, 2‐cis‐selectivity can be induced by remote participation of C4 or C6 ester groups …