Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous
cholesterol has been doubted because of the inability to detect dehydroepiandrosterone …

Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …

The aim of the present review, which highlights some relationships between sex hormones,
the CNS and pain, is to provide reference points for discussion on one of the most intriguing …

Estrogen and androgen are synthesized from cholesterol locally in hippocampal neurons of
adult animals. These neurosteroids are synthesized by cytochrome P450s and …

Rapid modulation of hippocampal synaptic plasticity by estrogen has long been a hot topic,
but analysis of molecular mechanisms via synaptic estrogen receptors has been seriously …

The hippocampus is a center for learning and memory as well as a target of Alzheimer's
disease in aged humans. Synaptic modulation by estrogen is essential to understand the …

The hippocampus synthesizes estrogen and androgen in addition to the circulating sex
steroids. Synaptic modulation by hippocampus-derived estrogen or androgen is essential to …