The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

A 'frontal variant of Alzheimer's disease'has been described in patients with predominant
behavioural or dysexecutive deficits caused by Alzheimer's disease pathology. The …

Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's
disease (AD) and by their caretakers. Working memory and long-term declarative memory …

We consider between-subject variance in brain function as data rather than noise. We
describe variability as a natural output of a noisy plastic system (the brain) where each …

Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest
neurodegenerative changes associated with each variant has implications for early …