Artificial intelligence aids in development of nanomedicines for cancer management

P Tan, X Chen, H Zhang, Q Wei, K Luo - Seminars in cancer biology, 2023 - Elsevier
Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

High-throughput sequencing technologies

JA Reuter, DV Spacek, MP Snyder - Molecular cell, 2015 - cell.com
The human genome sequence has profoundly altered our understanding of biology, human
diversity, and disease. The path from the first draft sequence to our nascent era of personal …

Advancements in next-generation sequencing

SE Levy, RM Myers - Annual review of genomics and human …, 2016 - annualreviews.org
The term next-generation sequencing is almost a decade old, but it remains the colloquial
way to describe highly parallel or high-output sequencing methods that produce data at or …

Translation elongation and recoding in eukaryotes

TE Dever, JD Dinman, R Green - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …

Next-generation sequencing platforms

ER Mardis - Annual review of analytical chemistry, 2013 - annualreviews.org
Automated DNA sequencing instruments embody an elegant interplay among chemistry,
engineering, software, and molecular biology and have built upon Sanger's founding …

Synonymous but not the same: the causes and consequences of codon bias

JB Plotkin, G Kudla - Nature Reviews Genetics, 2011 - nature.com
Despite their name, synonymous mutations have significant consequences for cellular
processes in all taxa. As a result, an understanding of codon bias is central to fields as …

Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth

X Dai, M Zhu, M Warren, R Balakrishnan… - Nature …, 2016 - nature.com
Bacteria growing under different conditions experience a broad range of demand on the rate
of protein synthesis, which profoundly affects cellular resource allocation. During fast growth …

Fluorescence enhancement at docking sites of DNA-directed self-assembled nanoantennas

GP Acuna, FM Möller, P Holzmeister, S Beater… - Science, 2012 - science.org
We introduce self-assembled nanoantennas to enhance the fluorescence intensity in a
plasmonic hotspot of zeptoliter volume. The nanoantennas are prepared by attaching one or …

A window into third-generation sequencing

EE Schadt, S Turner, A Kasarskis - Human molecular genetics, 2010 - academic.oup.com
First-and second-generation sequencing technologies have led the way in revolutionizing
the field of genomics and beyond, motivating an astonishing number of scientific advances …

The elongation, termination, and recycling phases of translation in eukaryotes

TE Dever, R Green - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …