Pharmacogenomics of Preeclampsia therapies: current evidence and future challenges for clinical implementation

P Chaemsaithong, M Biswas, W Lertrut… - Best Practice & …, 2023 - Elsevier
Preeclampsia is a pregnancy-specific disorder, and it is a leading cause of maternal and
perinatal morbidity and mortality. The application of pharmacogenetics to antihypertensive …

Potential biomarkers for late-onset and term preeclampsia: A scoping review

L Han, OJ Holland, F Da Silva Costa… - Frontiers in …, 2023 - frontiersin.org
Preeclampsia is a progressive, multisystem pregnancy disorder. According to the time of
onset or delivery, preeclampsia has been subclassified into early-onset (< 34 weeks) and …

Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta

HC Safford, KL Swingle, HC Geisler, AG Hamilton… - Small, 2023 - Wiley Online Library
During healthy pregnancy, the placenta develops to allow for exchange of nutrients and
oxygen between the mother and the fetus. However, placental dysregulation can lead to …

Preeclampsia and long-term risk of venous thromboembolism

E Havers-Borgersen, JH Butt, M Johansen… - JAMA network …, 2023 - jamanetwork.com
Importance As venous thromboembolism (VTE) remains one of the leading causes of
maternal mortality, identifying women at increased risk of VTE is of great importance …

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

DJ Dijkstra, FS van de Bovenkamp… - Proceedings of the …, 2023 - National Acad Sciences
Autoantibodies directed against complement component C1q are commonly associated with
autoimmune diseases, especially systemic lupus erythematosus. Importantly, these anti-C1q …

Deep hybrid model for maternal health risk classification in pregnancy: synergy of ANN and random forest

TO Togunwa, AO Babatunde… - Frontiers in Artificial …, 2023 - frontiersin.org
Introduction Maternal health is a critical aspect of public health that affects the wellbeing of
both mothers and infants. Despite medical advancements, maternal mortality rates remain …

New ideas for the prevention and treatment of preeclampsia and their molecular inspirations

A Sakowicz, M Bralewska… - International Journal of …, 2023 - mdpi.com
Preeclampsia (PE) is a pregnancy-specific disorder affecting 4–10% of all expectant women.
It greatly increases the risk of maternal and foetal death. Although the main symptoms …

T cell immunity and the etiology and pathogenesis of preeclampsia

S Saito, S Tsuda, A Nakashima - Journal of reproductive immunology, 2023 - Elsevier
Preeclampsia is more common in nulliparous women, their first pregnancies with a new
partner in multiparous women, pregnant women with short duration of cohabitation, and in …

[HTML][HTML] Hormonal determinants of growth and weight gain in the human fetus and preterm infant

L Page, N Younge, M Freemark - Nutrients, 2023 - mdpi.com
The factors controlling linear growth and weight gain in the human fetus and newborn infant
are poorly understood. We review here the changes in linear growth, weight gain, lean body …

Highly Flexible Deep-Learning-Based Automatic Analysis for Graphically Encoded Hydrogel Microparticles

JH Choi, W Jang, YJ Lim, SJ Mun, KW Bong - ACS sensors, 2023 - ACS Publications
Graphically encoded hydrogel microparticle (HMP)-based bioassay is a diagnostic tool
characterized by exceptional multiplex detectability and robust sensitivity and specificity …