Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

Background Lung cancer remains the most common cause of cancer-related deaths, with a
high incidence and mortality in both sexes worldwide. Chemoprevention has been the most …

Novel glutathione (GSH) redox-sensitive thiolated vitaminE-PEG1000-succinate (TPGH-SH)
was synthesized by conjugating TPGS with 4-amino thiophenol (4-ATP) and confirmed by …

Despite novel technologies, colon cancer remains undiagnosed and 25% of patients are
diagnosed with metastatic colon cancer. Resistant to chemotherapeutic agents is one of the …

Aim: To design, optimize and evaluate docetaxel-loaded chitosan nanoparticles with
(targeted) and without (nontargeted) cetuximab conjugation for the treatment of non-small …

Quercetin (Qu) is an important polyphenolic flavonoid which exhibits tremendous
antioxidant, anti-inflammatory and other health promoting effects. The aim of the current …

Pancreatic cancer is a malignant tumor of the digestive system. It is highly aggressive, easily
metastasizes, and extremely difficult to treat. This study aimed to analyze the genes that …

Objective We previously demonstrated the roflumilast inhibited cell proliferation and
increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of …

Phosphodiesterase-4 regulates the intracellular level of cAMP. Roflumilast, a selective PDE-
4 inhibitor was the first agent in this class to have reached the market for patients with …