Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Interferons (IFNs) are generally considered antiviral cytokines, yet the newly discovered IFN-
λ4 is linked with the failure to clear hepatitis C virus (HCV) infection either spontaneously or …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

BACKGROUND. Hepatitis C virus (HCV) infects approximately 170 million people worldwide
and may lead to cirrhosis and hepatocellular carcinoma in chronically infected individuals …

The interferon system protects mammals against virus infections. There are several types of
interferons, which are characterized by their ability to inhibit virus replication and resultant …

Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and
hepatocellular carcinoma worldwide. Both spontaneous and treatment-induced clearance of …

Elimination of hepatitis C virus (HCV) without the need for medical intervention, known as
spontaneous clearance (SC), occurs at a significantly lower rate than in the case of hepatitis …

Interferon lambda 4 gene (IFNL4) encodes IFN-λ4, a new member of the IFN-λ family with
antiviral activity. In humans IFNL4 open reading frame is truncated by a polymorphic frame …

Paralleling the first 30 years of the Journal of Hepatology we have witnessed huge
advances in our understanding of liver disease and physiology. Genetic advances have …

Hepatitis C virus (HCV) remains a public health problem of global importance, even in the
era of potent directly-acting antiviral drugs. In this chapter, I discuss immune responses to …