Bisphosphonates are a unique class of drugs. As a family, they are characterized
pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically …

The bisphosphonates represent a novel class of drugs, the use of which have opened up
major new approaches to the therapy of bone diseases. It has, however, taken over 30 years …

Synopsis Pamidronate [aminohydroxypropylidene diphosphonate disodium (APD),
disodium pamidronate] is an orally and intravenously active amino-substituted …

Bisphosphonates (BPs) are a group of well-established drugs that are applied in the
development of metabolic bone disorder-related therapies. There is increasing interest also …

Phosphonates are increasingly used as water-softening agents in detergents, care products,
and industrial processes. Despite poor biodegradability, high removal rates during …

Bisphosphonates is a class of chemical compounds finding extensive medical applications
against bone disorders including osteoporosis, Pagets' disease, etc. Non-N-containing …

Background: Porous tantalum has been shown to be effective in achieving bone ingrowth.
However, in some circumstances, bone quality or quantity may be insufficient to allow …

Pamidronate is a second‐generation bisphosphonate that undergoes negligible
biodegradation and is eliminated exclusively by renal excretions. Nineteen cancer patients …

An improved method for the determination of 4-amino-1-hydroxybutane-1, 1-bisphosphonic
acid (alendronate) in human urine and an assay in human plasma are described. The …

A high-performance liquid chromatographic (HPLC) method was developed using
diethylamine (DEA) solid-phase extraction (SPE), 9-fluorenylmethyl derivative (FMOC) and …