Epigenetics of colorectal cancer: biomarker and therapeutic potential
G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …
Long non-coding RNA in the pathogenesis of cancers
Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …
At present, cancer has become the leading cause of death worldwide. Most of the cancers …
Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …
comprehensive understanding of its molecular foundations to establish effective treatment …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-
range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus …
range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus …
[HTML][HTML] Colorectal cancer carcinogenesis: a review of mechanisms
Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …
common in men globally. CRC arises from one or a combination of chromosomal instability …
[HTML][HTML] Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer
T Liu, X Zhang, S Gao, F Jing, Y Yang, L Du, G Zheng… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer-secreted long non-coding RNAs (lncRNAs) are emerging mediators of cancer-host
cross talk. The aim of our study was to illustrate the clinical significance of the lncRNA …
cross talk. The aim of our study was to illustrate the clinical significance of the lncRNA …
H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal …
E Zhang, L Han, D Yin, X He, L Hong, X Si… - Nucleic acids …, 2017 - academic.oup.com
Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory
roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose …
roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose …
ChIPBase v2. 0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data
The abnormal transcriptional regulation of non-coding RNAs (ncRNAs) and protein-coding
genes (PCGs) is contributed to various biological processes and linked with human …
genes (PCGs) is contributed to various biological processes and linked with human …
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
Y Jiang, YY Jiang, JJ Xie, A Mayakonda… - Nature …, 2018 - nature.com
Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report
demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping …
demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping …