Hydrogels for protein delivery in tissue engineering

R Censi, P Di Martino, T Vermonden… - Journal of Controlled …, 2012 - Elsevier
Tissue defects caused by diseases or trauma present enormous challenges in regenerative
medicine. Recently, a better understanding of the biological processes underlying tissue …

[HTML][HTML] Macroscale delivery systems for molecular and cellular payloads

CJ Kearney, DJ Mooney - Nature materials, 2013 - nature.com
Macroscale drug delivery (MDD) devices are engineered to exert spatiotemporal control
over the presentation of a wide range of bioactive agents, including small molecules …

Biomaterials for the delivery of growth factors and other therapeutic agents in tissue engineering approaches to bone regeneration

CJ Kowalczewski, JM Saul - Frontiers in pharmacology, 2018 - frontiersin.org
Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Bone healing materials in the treatment of recalcitrant nonunions and bone defects

EC Rodríguez-Merchán - International Journal of Molecular Sciences, 2022 - mdpi.com
The usual treatment for bone defects and recalcitrant nonunions is an autogenous bone
graft. However, due to the limitations in obtaining autogenous bone grafts and the morbidity …

Effects of protein dose and delivery system on BMP-mediated bone regeneration

JD Boerckel, YM Kolambkar, KM Dupont, BA Uhrig… - Biomaterials, 2011 - Elsevier
Delivery of recombinant proteins is a proven therapeutic strategy to promote endogenous
repair mechanisms and tissue regeneration. Bone morphogenetic protein-2 (rhBMP-2) has …

Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man

D Gothard, EL Smith, JM Kanczler… - European cells & …, 2014 - eprints.soton.ac.uk
There is a growing socio-economic need for effective strategies to repair damaged bone
resulting from disease, trauma and surgical intervention. Bone tissue engineering has …

Local drug delivery for enhancing fracture healing in osteoporotic bone

L Kyllönen, M D'Este, M Alini, D Eglin - Acta biomaterialia, 2015 - Elsevier
Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …

Growth factor delivery: how surface interactions modulate release in vitro and in vivo

WJ King, PH Krebsbach - Advanced drug delivery reviews, 2012 - Elsevier
Biomaterial scaffolds have been extensively used to deliver growth factors to induce new
bone formation. The pharmacokinetics of growth factor delivery has been a critical regulator …

[HTML][HTML] Surface delivery of tunable doses of BMP-2 from an adaptable polymeric scaffold induces volumetric bone regeneration

M Bouyer, R Guillot, J Lavaud, C Plettinx, C Olivier… - Biomaterials, 2016 - Elsevier
The rapid and effective bone regeneration of large non-healing defects remains challenging.
Bioactive proteins, such as bone morphogenetic protein (BMP)-2, are proved their …

Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

G Bhakta, B Rai, ZXH Lim, JH Hui, GS Stein… - Biomaterials, 2012 - Elsevier
Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor, yet its clinical use
is limited by a short biological half-life, rapid local clearance and propensity for side effects …