Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury
W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …
below the injured segment. SCI not only results in physical and psychological harm to …
Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …
phase in the pathophysiological process of SCI concerns the well-known secondary injury …
From basics to clinical: a comprehensive review on spinal cord injury
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …
individuals each year. Over the past decades an enormous progress has been made in our …
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
J Laurén, DA Gimbel, HB Nygaard, JW Gilbert… - Nature, 2009 - nature.com
A pathological hallmark of Alzheimer's disease is an accumulation of insoluble plaque
containing the amyloid-β peptide of 40–42 amino acid residues. Prefibrillar, soluble …
containing the amyloid-β peptide of 40–42 amino acid residues. Prefibrillar, soluble …
Neurotrophins and their receptors: a convergence point for many signalling pathways
MV Chao - Nature Reviews Neuroscience, 2003 - nature.com
The neurotrophins are a family of proteins that are essential for the development of the
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …
Glial inhibition of CNS axon regeneration
Damage to the adult CNS often leads to persistent deficits due to the inability of mature
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …
Neural tissue engineering: strategies for repair and regeneration
CE Schmidt, JB Leach - Annual review of biomedical …, 2003 - annualreviews.org
▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon
JW Rowland, GWJ Hawryluk, B Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …
discusses important emerging regenerative approaches that have been translated into …
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
TL Dickendesher, KT Baldwin, YA Mironova… - Nature …, 2012 - nature.com
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-
associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting …
associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting …
Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
The most common inherited form of Frontotemporal Lobar Degeneration (FTLD) known
stems from Progranulin (GRN) mutation and exhibits TDP-43 plus ubiquitin aggregates …
stems from Progranulin (GRN) mutation and exhibits TDP-43 plus ubiquitin aggregates …