Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master
regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic …

Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as
inducible coregulators of nuclear receptors in the control of cellular energy metabolic …

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-
γ coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α−/−) mice were viable …

Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the
two conditions do not always coincide and the molecular determinants of" healthy" versus" …

Aims/hypothesis Insulin secretion in pancreatic islets is dependent upon mitochondrial
function and production of ATP. The transcriptional coactivator peroxisome proliferator …

Aims/hypothesis Intake of n-3 polyunsaturated fatty acids reduces adipose tissue mass,
preferentially in the abdomen. The more pronounced effect of marine-derived …

TCF7L2 variants have been consistently associated with type 2 diabetes (T2D) in
populations of different ethnic descent. Among them, the rs7903146 T allele is probably the …

This study was conducted to test the hypothesis that dietary supplementation of arginine, the
physiologic precursor of nitric oxide (NO), reduces fat mass in the Zucker diabetic fatty (ZDF) …