For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …

Nucleophilic fluorination is one of the fundamental reactions in organic chemistry, as well as
a convenient tool for the synthesis of fluorinated building blocks with a potential biological …

Selective introduction of a double bond motif into a multifunctional organic compound is
always a big challenge. The Horner–Wadsworth–Emmons reaction is one of the most …

Direct conversion of the α-hydroxyl group by para-toluenesulfonamide to yield α-(N-tosyl)
aminophosphonates is reported. α-Aminophosphonates 23a, b–37a, b were obtained from …

Eco-friendly and simple procedure has been developed for the synthesis of α-
aminophosphonates that act as topoisomerase II α-inhibiting anticancer agent, using 2 …

A series of novel fluorine containing α‐aminophosphonate derivatives (4 a–4 q) were
synthesized in excellent yield and high purity. All these novel Fluorinated α …

Herein, we present the application of fluorinated carbohydrate-derived building blocks for α-
hydroxy β-fluoro/β-trifluoromethyl and unsaturated phosphonates synthesis. Pudovik and …

Herein, we present an efficient synthesis of dipeptide analogues of α-fluorinated β-
aminophosphonates. Each step of the synthesis was optimized to provide excellent yields …

We report a simple protocol for the synthesis of α‐fluoro‐β‐aminophosphonates by the
regioselective fluorination of α‐hydroxy‐β‐aminophosphonates under mild conditions. The …

This review article covers the developments made in collaboration by groups of Professors
VP Kukhar and P. Bravo to the synthetic applications of sulfinyl compounds as versatile …