Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
CaM kinase: still inspiring at 40
KU Bayer, H Schulman - Neuron, 2019 - cell.com
Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
Dendritic cortical microcircuits approximate the backpropagation algorithm
J Sacramento, R Ponte Costa… - Advances in neural …, 2018 - proceedings.neurips.cc
Deep learning has seen remarkable developments over the last years, many of them
inspired by neuroscience. However, the main learning mechanism behind these advances …
inspired by neuroscience. However, the main learning mechanism behind these advances …
The plasticitome of cortical interneurons
AR McFarlan, CYC Chou, A Watanabe… - Nature Reviews …, 2023 - nature.com
Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …
coding for a percept are bound together via associative long-term synaptic plasticity. In this …
Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …
information processing in neural circuits. However, little is known about the spatial principles …
[HTML][HTML] Regulation of circuit organization and function through inhibitory synaptic plasticity
Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
The formation and maintenance of spatial representations within hippocampal cell
assemblies is strongly dictated by patterns of inhibition from diverse interneuron …
assemblies is strongly dictated by patterns of inhibition from diverse interneuron …
Spike timing-dependent plasticity and memory
D Debanne, Y Inglebert - Current Opinion in Neurobiology, 2023 - Elsevier
Spike timing-dependent plasticity (STDP) is a bidirectional form of synaptic plasticity
discovered about 30 years ago and based on the relative timing of pre-and post-synaptic …
discovered about 30 years ago and based on the relative timing of pre-and post-synaptic …
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Cellular mechanisms that regulate the interplay of synaptic excitation and inhibition are
thought to be central to the functional stability of healthy neuronal circuits. A growing body of …
thought to be central to the functional stability of healthy neuronal circuits. A growing body of …
Keeping your brain in balance: Homeostatic regulation of network function
W Wen, GG Turrigiano - Annual Review of Neuroscience, 2024 - annualreviews.org
To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …
microcircuits must be capable of reconfiguring in response to experience, while carefully …