In many settings, tumor-associated inflammation, supported mainly by innate immune cells,
contributes to tumor growth. Initial innate activation triggers secretion of inflammatory …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with
antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in …

The mammalian intestine harbors trillions of beneficial commensal bacteria that are
essential for the development of the immune system and for maintenance of physiologic …

After their development in the thymus, mature T cells are maintained in the periphery by two
sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and …

It remains unknown what causes inflammatory bowel disease (IBD), including signaling
networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and …

Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina
propria, where their basal function remains largely unexplored. In this study, by examining …

The intestinal epithelium—which constitutes the interface between the enteric microbiota
and host tissues—actively contributes to the maintenance of mucosal homeostasis and …

Summary Interleukin-7 (IL-7) availability determines the size and proliferative state of the
resting T cell pool. However, the mechanisms that regulate steady-state IL-7 amounts are …

IL-7 is a cytokine crucial for development and maintenance of lymphocytes and other
hematopoietic cells. However, how IL-7–expressing cells are distributed in lymphoid organs …