ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …

Genome-wide scanning for signals of recent positive selection is essential for a
comprehensive and systematic understanding of human adaptation. Here, we present a …

The clinical efficacy of a systemically administered drug acting on the central nervous
system depends on its ability to pass the blood-brain barrier, which is regulated by …

Background and Objective A large interindividual variability exists in the plasma
concentrations of repaglinide. Our aim was to investigate possible associations between the …

We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1
gene to perform association analysis in Slovenian patients with inflammatory bowel …

Methadone is a mu-opioid receptor agonist used for treating opiate dependence. The range
of effective methadone doses is broad. Part of the large inter-individual variability in efficacy …

Several studies have found strikingly different allele frequencies between continents. This
has been mainly interpreted as being due to local adaptation. However, demographic …

The membrane transport protein P-glycoprotein (P-gp) is an interesting candidate for
individual differences in response to antipsychotics. To present an overview of the current …

Addiction to opiates and illicit use of psychostimulants is a chronic, relapsing brain disease
that, if left untreated, can cause major medical, social, and economic problems. This article …