Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are
involved in movement control and reward-related cognition. In Parkinson's disease …

A fundamental interest in developmental neuroscience lies in the ability to map the complete
single-cell lineages within the brain. To this end, we developed a CRISPR editing-based …

Electrochemical sensors provide means for real-time monitoring of neurotransmitter release
events, which is a relatively easy process in simple electrolytes. However, this does not …

Neurological diseases are a major cause of the global burden of disease. Although the
mechanisms of the occurrence and development of neurological diseases are not fully clear …

Midbrain organoids derived from human induced pluripotent stem cells have emerged as a
promising in vitro model for studying the molecular and cellular mechanisms in Parkinsons …

Human brain development is spatially and temporally complex. Insufficient access to human
brain tissue and inadequacy of animal models have limited the study of brain development …

Motivated by the growing number of single cell RNA sequencing datasets (scRNAseq)
revealing the cellular heterogeneity in complex tissues, particularly in brain and induced …

Alpha-synuclein (αS) is a small, presynaptic neuronal protein encoded by the SNCA gene.
Point mutations and gene multiplication of SNCA cause rare familial forms of Parkinson's …

We developed CREST (CRISPR editing-based lineage-specific tracing) to enable high-
throughput mapping of single-cell lineages in any Cre lineage of interest in mice. In addition …