Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors

CB Mantilla, GC Sieck - Respiratory physiology & neurobiology, 2011 - Elsevier
Phrenic motoneurons are located in the cervical spinal cord and innervate the diaphragm
muscle, the main inspiratory muscle in mammals. Similar to other skeletal muscles, phrenic …

Functional recovery after cervical spinal cord injury: role of neurotrophin and glutamatergic signaling in phrenic motoneurons

LC Gill, HM Gransee, GC Sieck, CB Mantilla - Respiratory physiology & …, 2016 - Elsevier
Cervical spinal cord injury (SCI) interrupts descending neural drive to phrenic motoneurons
causing diaphragm muscle (DIAm) paralysis. Recent studies using a well-established model …

Rapid and robust restoration of breathing long after spinal cord injury

PM Warren, SC Steiger, TE Dick… - Nature …, 2018 - nature.com
There exists an abundance of barriers that hinder functional recovery following spinal cord
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …

Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury

CB Mantilla, HM Gransee, WZ Zhan, GC Sieck - Experimental neurology, 2013 - Elsevier
AC 2 cervical spinal cord hemisection (SH) interrupts descending inspiratory-related drive to
phrenic motoneurons located between C 3 and C 5 in rats, paralyzing the ipsilateral …

Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury

MJ Fogarty, WZ Zhan, VF Simmon… - The Journal of …, 2023 - Wiley Online Library
Spinal cord hemisection at C2 (C2SH), sparing the dorsal column is widely used to
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …

Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury

C Nicaise, TJ Hala, DM Frank, JL Parker… - Experimental …, 2012 - Elsevier
Respiratory dysfunction is the leading cause of morbidity and mortality following traumatic
spinal cord injury (SCI). Injuries targeting mid-cervical spinal cord regions affect the phrenic …

Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis

JL Warren, L Grandjean, DAJ Moore, A Lithgow… - BMC medicine, 2018 - Springer
Background Congregate settings may serve as institutional amplifiers of tuberculosis (TB)
and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and …

Localized delivery of brain-derived neurotrophic factor-expressing mesenchymal stem cells enhances functional recovery following cervical spinal cord injury

HM Gransee, WZ Zhan, GC Sieck… - Journal of …, 2015 - liebertpub.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are important in
modulating neuroplasticity and promoting recovery after spinal cord injury. Intrathecal …

Recruitment of rat diaphragm motor units across motor behaviors with different levels of diaphragm activation

YB Seven, CB Mantilla… - Journal of Applied …, 2014 - journals.physiology.org
Phrenic motor neurons are recruited across a range of motor behaviors to generate varying
levels of diaphragm muscle (DIAm) force. We hypothesized that DIAm motor units are …

Ampakines stimulate diaphragm activity after spinal cord injury

S Rana, MD Sunshine, JJ Greer… - Journal of Neurotrauma, 2021 - liebertpub.com
Respiratory compromise after cervical spinal cord injury (SCI) is a leading cause of mortality
and morbidity. Most SCIs are incomplete, and spinal respiratory motoneurons as well as …