Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder with a clinical
presentation characterized by memory impairment and executive dysfunction. Our group …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Brain imaging with diffusion-weighted MRI (dMRI) is sensitive to microstructural white matter
(WM) changes associated with brain aging and neurodegeneration. In its third phase, the …

Cerebrospinal fluid (CSF) neurofilament light (NfL) concentration has reproducibly been
shown to reflect neurodegeneration in brain disorders, including Alzheimer's disease (AD) …

Background Epidemiologic studies have shown that Alzheimer's disease (AD) and related
dementias (ADRD) are seen more frequently with asthma, especially with greater asthma …

Automated classification of Alzheimer's disease (AD) plays a key role in the diagnosis of
dementia. In this paper, we solve for the first time a direct four-class classification problem …

Background: The fornix is the primary axonal tract of the hippocampus, connecting it to
modulatory subcortical structures. This review reveals that fornix damage causes cognitive …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by
progressive dementia, and amnestic mild cognitive impairment (aMCI) has been defined as …