The concept of gene therapy originated in the mid twentieth century and was perceived as a
revolutionary technology with the promise to cure almost any disease of which the molecular …

One of the most powerful tools that the molecular biology revolution has given us is the
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …

The genetic and physiological similarities between mice and humans have focused
considerable attention on rodents as potential models of human health and disease …

Ecdysteroids are widely used as inducers for gene-switch systems based on insect
ecdysteroid receptors and genes of interest placed under the control of ecdysteroid …

Transgenic animals are extensively used to study in vivo gene function as well as to model
human diseases. The technology for producing transgenic animals exists for a variety of …

Steroid hormones are a group of lipophilic hormones that are believed to enter cells by
simple diffusion to regulate diverse physiological processes through intracellular nuclear …

Strategies for conditional induction of transgene expression in mice are likely to be valuable
for testing the role of candidate genes in disease pathogenesis. We have developed a …

Zooecdysteroids (arthropod steroid hormones) regulate the development of arthropods and
probably many other invertebrates. Phytoecdysteroids are analogues occurring in a wide …

Background A number of expression systems have been developed where transgene
expression can be regulated. They all have specific characteristics making them more …

It has become apparent that the clinical success anticipated in the field of gene therapy has
been limited by progress in several of the fundamental areas of genetics, molecular and …