The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or
prevention of genetic disorders. The success rate of gene therapy depends on the …

The superiority of in vitro 3D cultures over conventional 2D cell cultures is well recognized
by the scientific community for its relevance in mimicking the native tissue architecture and …

Stem cell encapsulation in hydrogels has been widely employed in tissue engineering,
regenerative medicine, organ-on-a-chip devices and gene delivery; however, fabrication of …

Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …

Natural polymeric scaffolds can be used for tissue engineering applications such as cell
delivery and cell-free supporting of native tissues. This is because of their desirable …

Abstract Background Three-dimensional (3D) culture of mesenchymal stem cells has
become an important research and development topic. However, comprehensive analysis of …

Stem cell spheroids have been studied extensively in organoid culture and therapeutic
transplantation. Herein, hydrogels with an embossed surface (HES) were developed as an …

Top-down tissue engineering aims to produce functional tissues using biomaterials as
scaffolds, thus providing cues for cell proliferation and differentiation. Conversely, the bottom …

Despite significant progress in the field of biomaterials for bone repair, the lack of attention to
the vascular and nervous networks within bone implants could be one of the main reasons …

In biomaterials R&D, conventional monolayer cell culture on flat/planar material samples,
such as films, is still commonly employed at early stages of the assessment of interactions of …