To perform their functions, transcription factors and DNA-repair/modifying enzymes
randomly search DNA in order to locate their specific targets on DNA. Discrete-state …

All major biological processes start after protein molecules known as transcription factors
detect specific regulatory sequences on DNA and initiate genetic expression by associating …

Associations of transcription factors (TFs) with specific sites on DNA initiate major cellular
processes. But DNA in eukaryotic cells is covered by nucleosomes which prevent TFs from …

Transfer of genetic information starts with transcription factors (TFs) binding to specific sites
on DNA. But in living cells, DNA is mostly covered by nucleosomes. There are proteins …

Protein searching and binding to specific sites on DNA is a fundamentally important process
that marks the beginning of all major cellular transformations. While the dynamics of protein …

In eukaryotic cells, DNA is bound to nucleosome particles, allowing for chromatin to be
efficiently confined in small cellular volumes. But these compact structures are not rigid, and …

Many fundamental biophysical processes involving gene regulation and gene editing rely, at
the molecular level, on an intricate methodology of searching and locating the precise target …

The binding of proteins to their respective specific sites on the DNA through facilitated
diffusion serves as the initial step of various important biological processes. While this …

Association of protein transcription factors (TFs) to specific DNA sites in promoter regions is
the fundamental event that initiates gene regulation. However eukaryotic DNA is mostly …

The target search process in DNA is the very first step for very fundamental biochemical and
biophysical steps that follow. Gene transcription and formation of protein-DNA structures are …