Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

L Paixão, RB Ramos, A Lavarda, DM Morsh… - Reproductive Biology …, 2017 - Springer
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9–18% of
women in reproductive age that causes hyperandrogenism and infertility due to …

Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway

B Xu, W Dai, L Liu, H Han, J Zhang, X Du, X Pei… - Endocrine …, 2022 - jstage.jst.go.jp
Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a
variety of clinical features, including anovulation, hyperandrogenism, and ovarian …

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model

A Benrick, B Chanclón, P Micallef… - Proceedings of the …, 2017 - National Acad Sciences
Adiponectin, together with adipocyte size, is the strongest factor associated with insulin
resistance in women with polycystic ovary syndrome (PCOS). This study investigates the …

Resveratrol improves follicular development of PCOS rats by regulating the glycolytic pathway

A Liang, L Huang, H Liu, W He, X Lei… - Molecular Nutrition & …, 2021 - Wiley Online Library
Scope Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder
that can cause infertility; however, the underlying mechanisms remain ill‐defined, and there …

Activation of endoplasmic reticulum stress in granulosa cells from patients with polycystic ovary syndrome contributes to ovarian fibrosis

N Takahashi, M Harada, Y Hirota, E Nose… - Scientific reports, 2017 - nature.com
Recent studies report the involvement of intra-ovarian factors, such as inflammation and
oxidative stress, in the pathophysiology of polycystic ovary syndrome (PCOS), the most …

Hyperandrogenism and insulin resistance‐induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in …

Y Zhang, W Zhao, H Xu, M Hu, X Guo… - The Journal of …, 2019 - Wiley Online Library
Key points Women with polycystic ovary syndrome (PCOS) commonly suffer from
miscarriage, but the underlying mechanisms remain unknown. Herein, pregnant rats …

Effect of maternal PCOS and PCOS-like phenotype on the offspring's health

M Puttabyatappa, RC Cardoso… - Molecular and cellular …, 2016 - Elsevier
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both
reproductive and metabolic abnormalities affecting women of reproductive age. While the …

[HTML][HTML] Up-regulation of long noncoding RNA SRA promotes cell growth, inhibits cell apoptosis, and induces secretion of estradiol and progesterone in ovarian …

Y Li, H Wang, D Zhou, T Shuang, H Zhao… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Background Increasing evidence indicates that long noncoding RNAs (LncRNAs) play a key
role in multiple pathological processes. It has been shown that LncRNA steroid receptor …

Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome

M Puttabyatappa… - Journal of molecular …, 2018 - jme.bioscientifica.com
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting women
of reproductive age. The origin of PCOS is still not clear and appears to be a function of …