Homologous recombination and its regulation
L Krejci, V Altmannova, M Spirek… - Nucleic acids research, 2012 - academic.oup.com
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude
of deleterious DNA lesions, which arise constantly in every cell. Processes that support …
of deleterious DNA lesions, which arise constantly in every cell. Processes that support …
Mismatch repair during homologous and homeologous recombination
Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
RAD52: paradigm of synthetic lethality and new developments
MJ Rossi, SF DiDomenico, M Patel, AV Mazin - Frontiers in Genetics, 2021 - frontiersin.org
DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …
damage that cause genomic instability that lead to cancer development. The highest fidelity …
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
K Cramer-Morales… - Blood, The Journal …, 2013 - ashpublications.org
Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous
and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2 …
and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2 …
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing
Gene disruption by clustered regularly interspaced short palindromic repeats (CRISPR)–
CRISPR-associated protein 9 (Cas9) is highly efficient and relies on the error-prone non …
CRISPR-associated protein 9 (Cas9) is highly efficient and relies on the error-prone non …
Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation
E Malacaria, GM Pugliese, M Honda, V Marabitti… - Nature …, 2019 - nature.com
Stabilisation of stalled replication forks prevents excessive fork reversal and their
pathological degradation, which can undermine genome integrity. Here we investigate a …
pathological degradation, which can undermine genome integrity. Here we investigate a …
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD
Abstract Background The C9ORF72 hexanucleotide repeat expansion is the most common
known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response
Disrupting either the DNA annealing factor RAD52 or the A-family DNA polymerase POLQ
can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor …
can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor …
Making choices: DNA replication fork recovery mechanisms
CM Kondratick, MT Washington, M Spies - Seminars in cell & …, 2021 - Elsevier
DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …