The use of biomarkers as early warning systems in the evaluation of disease risk has
increased markedly in the last decade. Biomarkers are indicators of typical biological …

De Ritis described the ratio between the serum levels of aspartate transaminase (AST) and
alanine transaminase (ALT) almost 50 years ago. While initially described as a characteristic …

Clinicians are required to assess abnormal liver chemistries on a daily basis. The most
common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate …

These updated guidelines on the management of abnormal liver blood tests have been
commissioned by the Clinical Services and Standards Committee (CSSC) of the British …

ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a
seemingly healthy patient can present a challenge for the clinician. In this review we provide …

The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes
and is considered to be a highly sensitive and fairly specific preclinical and clinical …

Drug-induced liver injury (DILI) is a problem of increasing significance, but has been a long-
standing concern in the treatment of tuberculosis (TB) infection. The liver has a central role …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Liver plays a central role in the metabolism and excretion of xenobiotics which makes it
highly susceptible to their adverse and toxic effects. Liver injury caused by various toxic …

Background: MicroRNAs (miRNAs) are endogenous, small noncoding RNAs. Because of
their size, abundance, tissue specificity, and relative stability in plasma, miRNAs hold …