The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

The canonical Wnt pathway has gathered much attention in recent years owing to its
fundamental contribution to metazoan development, tissue homeostasis and human …

Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the
nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of …

Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …

Epigenetic modifications of chromatin play an important role in the regulation of gene
expression. KMT4/Dot1 is a conserved histone methyltransferase capable of methylating …

Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by
diverse etiology, activation of multiple signal transduction pathways, and various gene …

One of the early surprises in the study of cell adhesion was the discovery that β-catenin
plays dual roles, serving as an essential component of cadherin-based cell–cell adherens …

Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous
polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and …