[HTML][HTML] Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
S Schulz, M Becker, MR Groseclose, S Schadt… - Current opinion in …, 2019 - Elsevier
Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling
Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization
mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous mapping of …
mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous mapping of …
Fatty acid synthesis is required for breast cancer brain metastasis
Brain metastases are refractory to therapies that control systemic disease in patients with
human epidermal growth factor receptor 2-positive breast cancer and the brain …
human epidermal growth factor receptor 2-positive breast cancer and the brain …
The treatment of tuberculosis
CA Peloquin, GR Davies - Clinical Pharmacology & …, 2021 - Wiley Online Library
Tuberculosis (TB) remains a leading cause of infectious death worldwide, and poverty is a
major driver. Clinically, TB presents as “latent” TB and active TB disease, and the treatment …
major driver. Clinically, TB presents as “latent” TB and active TB disease, and the treatment …
Metabolomics in infectious diseases and drug discovery
Metabolomics has emerged as an invaluable tool that can be used along with genomics,
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …
Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation
Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) is a
powerful technique for visualising the spatial locations of lipids in biological tissues …
powerful technique for visualising the spatial locations of lipids in biological tissues …
Multimodal imaging based on vibrational spectroscopies and mass spectrometry imaging applied to biological tissue: a multiscale and multiomics review
Molecular imaging has the potential to unearth important spatial and temporal relationships
in biological systems, including intercellular signaling as well as environmentally-cued …
in biological systems, including intercellular signaling as well as environmentally-cued …
Caseum: a niche for Mycobacterium tuberculosis drug-tolerant persisters
JP Sarathy, V Dartois - Clinical microbiology reviews, 2020 - Am Soc Microbiol
Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …
Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy
RC Lavin, S Tan - PLoS Pathogens, 2022 - journals.plos.org
A hallmark of Mycobacterium tuberculosis (Mtb) infection is the marked heterogeneity that
exists, spanning lesion type differences to microenvironment changes as infection …
exists, spanning lesion type differences to microenvironment changes as infection …
MALDI mass spectrometry imaging: a potential game-changer in a modern microbiology
M Feucherolles, G Frache - Cells, 2022 - mdpi.com
Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry
(MALDI-TOF MS) is routinely implemented as the reference method for the swift and …
(MALDI-TOF MS) is routinely implemented as the reference method for the swift and …