[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models

CGJ Guerrin, J Doorduin, IE Sommer… - … & Biobehavioral Reviews, 2021 - Elsevier
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …

New insights into the protection of dietary components on anxiety, depression, and other mental disorders caused by contaminants and food additives

RG Xiong, J Li, J Cheng, SX Wu, SY Huang… - Trends in Food Science …, 2023 - Elsevier
Background Several harmful substances can get into the human body easily through
different ways, including foods, drinking water, air, and so on. Moreover, there are a variety …

Multifactorial origin of neurodevelopmental disorders: approaches to understanding complex etiologies

A De Felice, L Ricceri, A Venerosi, F Chiarotti… - Toxics, 2015 - mdpi.com
A significant body of evidence supports the multifactorial etiology of neurodevelopmental
disorders (NDDs) affecting children. The present review focuses on early exposure to …

Schizophrenia and depression co-morbidity: what we have learned from animal models

JN Samsom, AHC Wong - Frontiers in psychiatry, 2015 - frontiersin.org
Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …

Animal models of gene–environment interaction in schizophrenia: A dimensional perspective

Y Ayhan, R McFarland, MV Pletnikov - Progress in neurobiology, 2016 - Elsevier
Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …

A developmental perspective on early-life exposure to neurotoxicants

DC Bellinger, JA Matthews-Bellinger, K Kordas - Environment international, 2016 - Elsevier
Background Studies of early-life neurotoxicant exposure have not been designed, analyzed,
or interpreted in the context of a fully developmental perspective. Objectives The goal of this …

Gene× environment interactions in schizophrenia: evidence from genetic mouse models

P Moran, J Stokes, J Marr, G Bock… - Neural …, 2016 - Wiley Online Library
The study of gene× environment, as well as epistatic interactions in schizophrenia, has
provided important insight into the complex etiopathologic basis of schizophrenia. It has also …

Utility and validity of DISC1 mouse models in biological psychiatry

T Tomoda, A Sumitomo, H Jaaro-Peled, A Sawa - Neuroscience, 2016 - Elsevier
We have seen an era of explosive progress in translating neurobiology into etiological
understanding of mental disorders for the past 10–15 years. The discovery of Disrupted-in …

Adolescent Δ9-tetrahydrocannabinol exposure and astrocyte-specific genetic vulnerability converge on nuclear factor-κB–cyclooxygenase-2 signaling to impair …

Y Jouroukhin, X Zhu, AV Shevelkin, Y Hasegawa… - Biological …, 2019 - Elsevier
Background Although several studies have linked adolescent cannabis use to long-term
cognitive dysfunction, there are negative reports as well. The fact that not all users develop …

Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models

TV Lipina, JC Roder - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Abstract Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it
predisposes individuals to a wide range of mental illnesses. Notably, a number of genes …