Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

The complex process of apoptosis is orchestrated by caspases, a family of cysteine
proteases with unique substrate specificities. Accumulating evidence suggests that cell …

Curcumin, a natural, biologically active compound extracted from rhizomes of Curcuma
species, has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative …

At the onset of anaphase, a caspase-related protease (separase) destroys the link between
sister chromatids by cleaving the cohesin subunit Scc1. During most of the cell cycle …

Chrysin is a natural, biologically active compound extracted from many plants, honey, and
propolis. It possesses potent anti-inflammation, anti-cancer, and anti-oxidation properties …

accepted March 6, 2007 b-Sitosterol is the main dietary phytosterol found in plants and has
been shown to inhibit proliferation and induce apoptosis in human solid tumors such as …

Resveratrol has been shown to induce anti-proliferation and apoptosis of human cancer cell
lines. In the present study, we determined the effect of high intracellular levels of the anti …

Cordyceps militaris is well known as a traditional medicinal mushroom and is a potentially
interesting candidate for use in cancer treatment. In this study, the potential of the water …

Arsenic trioxide has recently been shown to inhibit growth and induce apoptosis in acute
promyelocytic leukemia (APL), but little is known about the molecular mechanisms …

Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many
cruciferous vegetables including broccoli and cauliflower. Its inhibitory effects on tumor cell …