The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

Modification of proteins by the covalent attachment of ubiquitin is a key regulatory
mechanism of many cellular processes including protein degradation by the 26S pro …

Background: Pathological cardiac hypertrophy can lead to heart failure and is one of the
leading causes of death globally. Understanding the molecular mechanism of pathological …

Abstract Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals
remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 …

Background: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …

The ubiquitin–proteasome system facilitates the degradation of damaged proteins and
regulators of growth and stress response. Alterations in this proteolytic system are …

Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk
factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS …

Tankyrase-1 and-2 are closely related poly (ADP-ribose) polymerases that use an ankyrin-
repeat domain to bind diverse proteins, including TRF (telomere-repeat binding factor)-1 …

Insufficient invasion ability of trophoblasts might be associated with the development of
recurrent miscarriage (RM). Ubiquitin‐specific protease 25 (USP25) can regulate the …

The ubiquitin proteasome system is widely postulated to be a new and important field of
drug discovery for the future, with the ubiquitin specific proteases (USPs) representing one …