[HTML][HTML] HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

[HTML][HTML] Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy

Y Lang, Y Lyu, Y Tan, Z Hu - Frontiers in Immunology, 2023 - frontiersin.org
Hematological malignancy is a disease arisen by complicate reasons that seriously
endangers human health. The research on its pathogenesis and therapies depends on the …

Human T-cell lymphotropic virus type-1: a lifelong persistent infection, yet never truly silent

A Hirons, G Khoury, DFJ Purcell - The Lancet Infectious Diseases, 2021 - thelancet.com
Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key
communities, such as Indigenous Australians living in remote areas, greater than 45% of …

[HTML][HTML] NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

[HTML][HTML] Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis

A Dykie, T Wijesinghe, AB Rabson, K Madugula… - Pathogens, 2020 - mdpi.com
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated
with various clinical syndromes including co-infection with Strongyloides stercoralis, which is …

HTLV-1 replication and adult T cell leukemia development

CZ Giam - Viruses and Human Cancer: From Basic Science to …, 2021 - Springer
Human T-cell leukemia virus type 1 (HTLV-1) is a complex human delta retrovirus that
infects an estimated 10–20 million people worldwide (Gessain and Cassar 2012). HTLV-1 …

[HTML][HTML] Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence

S Sarkis, V Galli, R Moles, D Yurick, G Khoury… - Retrovirology, 2019 - Springer
The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo's
group, is the etiologic agent of both cancer and inflammatory diseases. Despite …

[HTML][HTML] The role of Bcl-xL protein in viral infections

Z Wyżewski, W Świtlik, MB Mielcarska… - International Journal of …, 2021 - mdpi.com
Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis
pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally …

[HTML][HTML] Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of …

LE Springer, JB Patton, T Zhan… - PLoS neglected …, 2021 - journals.plos.org
Viral and parasitic coinfections are known to lead to both enhanced disease progression
and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic …

[HTML][HTML] Infection of the Ex Vivo tonsil model by HTLV-1 Envelope-pseudotyped viruses

M Langlois, S Bounou, MJ Tremblay, B Barbeau - Pathogens, 2023 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of adult T-cell
leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis. Its …