The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor
expressed in myeloid cells, with crucial functions in antifungal responses. However, over …

The specialties of allergy and clinical immunology have entered the era of precision
medicine with the stratification of diseases into distinct disease subsets, specific diagnoses …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Environmental allergens, including fungi, insects and mites, trigger type 2 immunity;
however, the innate sensing mechanisms and initial signaling events remain unclear …

The molecular basis for the propensity of a small number of environmental proteins to
provoke allergic responses is largely unknown. Herein, we report that mite group 13 …

C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse
functions ranging from embryonic development to immune function. One subgroup of CLRs …

Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic
small‐molecule ligands. Ligand‐binding specificities can be strict or promiscuous. Serum …

Pathologic roles of innate immunity in neurologic disorders are well described, but their
beneficial aspects are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely …

Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC
phenotype is an important mechanism for establishing peripheral tolerance to self-antigens …

Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian
myeloid cells. Dectin-1 recognizes β-glucans and elicits antifungal proinflammatory immune …