The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts
and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside …

Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

Background The article provides the scientific documentation for the 3D animated film–
“Osseointegration–Communication of cells”. Aim The aim of this article and of the film is to …

Bone has long been known to be responsive to mechanical loading. For at least 25years it
has been known that osteocytes sense mechanical load, and because of their response to …

Skeletal fracture has recently emerged as a complication of obesity. Given the normal or
better than normal bone mineral density (BMD), the skeletal fragility of these patients …

Background: Obesity is associated with hyperparathyroidism and increased bone mass and
turnover, but their pathogeneses are unclear. Aims: Our aim was to determine in obesity …

Cell–cell and cell–matrix interactions mediated by cell adhesion molecules are important
mechanisms controlling cell fate and function. Here, we review recent advances in the …

Osteoblasts are integral to the development, growth, function, repair and maintenance of
bone. The osteoblast forms organic, non-mineralized bone matrix and is involved in complex …