B cell memory: building two walls of protection against pathogens
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
Role of B cells as antigen presenting cells
B cells have been long studied for their role and function in the humoral immune system.
Apart from generating antibodies and an antibody-mediated memory response against …
Apart from generating antibodies and an antibody-mediated memory response against …
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination
Feedback inhibition of humoral immunity by antibodies was first documented in 1909.
Subsequent studies showed that, depending on the context, antibodies can enhance or …
Subsequent studies showed that, depending on the context, antibodies can enhance or …
T follicular helper cell biology: a decade of discovery and diseases
S Crotty - Immunity, 2019 - cell.com
Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …
B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
Remembrance of things past: long-term B cell memory after infection and vaccination
AKE Palm, C Henry - Frontiers in immunology, 2019 - frontiersin.org
The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …
memory. The immune system can remember previously encountered pathogens, and …