Exploring dendrimer-based drug delivery systems and their potential applications in cancer immunotherapy

S Mukherjee, S Mukherjee, MAS Abourehab… - European Polymer …, 2022 - Elsevier
Cancer immunotherapy has been researched as a major modality of treatment which
involves activating the immune system of the patient to fight against tumor cells. Dendrimers …

New advances in general biomedical applications of PAMAM dendrimers

RV Araújo, SS Santos, E Igne Ferreira, J Giarolla - Molecules, 2018 - mdpi.com
Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …

Methods to improve the immunogenicity of plasmid DNA vaccines

D Eusébio, AR Neves, D Costa, S Biswas, G Alves… - Drug Discovery …, 2021 - Elsevier
DNA vaccines have emerged as innovative approaches that have great potential to
overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

[HTML][HTML] Advances in the polymeric delivery of nucleic acid vaccines

G Chen, B Zhao, EF Ruiz, F Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
Nucleic acid vaccines, especially messenger RNA (mRNA) vaccines, display unique
benefits in the current COVID-19 pandemic. The application of polymeric materials as …

Recent progress in dendrimer-based nanomedicine development

Y Kim, EJ Park, DH Na - Archives of pharmacal research, 2018 - Springer
Dendrimers offer well-defined nanoarchitectures with spherical shape, high degree of
molecular uniformity, and multiple surface functionalities. Such unique structural properties …

Cell-penetrating peptides: efficient vectors for vaccine delivery

J Yang, Y Luo, MA Shibu, I Toth… - Current drug …, 2019 - ingentaconnect.com
Subunit vaccines are composed of pathogen fragments that, on their own, are generally
poorly immunogenic. Therefore, the incorporation of an immunostimulating agent, eg …

Peptide-containing nanoformulations: Skin barrier penetration and activity contribution

T Zhang, X Luo, K Xu, W Zhong - Advanced Drug Delivery Reviews, 2023 - Elsevier
Transdermal drug delivery presents a less invasive pathway, circumventing the need to pass
through the gastrointestinal tract and liver, thereby reducing drug breakdown, initial …

[HTML][HTML] Starburst pamam dendrimers: Synthetic approaches, surface modifications, and biomedical applications

R Kharwade, S More, A Warokar, P Agrawal… - Arabian Journal of …, 2020 - Elsevier
Dendrimers are having novel three dimensional, synthetic hyperbranched, nano-polymeric
structure. Among all of the dendrimers, Poly-amidoamine (PAMAM) dendrimer are used …

Recent advances in degradable biomedical polymers for prevention, diagnosis and treatment of diseases

S Zhang, H Fang, H Tian - Biomacromolecules, 2024 - ACS Publications
Biomedical polymers play a key role in preventing, diagnosing, and treating diseases,
showcasing a wide range of applications. Their unique advantages, such as rich source …