The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

There has been a sea change in our view of transcription regulation during the past decade
(Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al …

Neutrophils are the most abundant immune cell type in the blood and constitute the first line
of defense against invading pathogens. Despite their important role in many diseases, they …

Healthy individuals have soluble (extracellular) DNA in their blood, and increased amounts
are present in cancer patients. Here we report the detection of specific sequences of the …

The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that
controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process …

Abstract c-myc, N-myc and L-myc are the three members of the myc oncoprotein family
whose role in the pathogenesis of many human neoplastic diseases has received wide …