Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four
families of peptides have been purified from scorpion venom. In this article, the classification …

Among the different scorpion species, Buthus martensi Karsch (BmK), a widely distributed
scorpion species in Asia, has received a lot of attention. Indeed, over the past decade, more …

Animal venoms and toxins are now recognized as major sources of bioactive molecules that
may be tomorrow's new drug leads. Their complexity and their potential as drug sources …

A new toxin, named HsTX1, has been identified in the venom of Heterometrus spinnifer
(Scorpionidae), on the basis of its ability to block the rat Kv1. 3 channels expressed in …

A novel cytotoxic linear peptide, IsCT, was characterized from scorpion Opisthacanthus
madagascariensis. It is a linear peptide with a molecular weight of 1501.9 Da composed of …

Venoms are rich source of several bioactive compounds that possess therapeutic potentials.
The different constituents of scorpion venom can modulate cell proliferation, cell growth and …

The biophysical properties of small conductance Ca 2+-activated K+(SK) channels are well
suited to underlie afterhyperpolarizations (AHPs) shaping the firing patterns of a …

cDNA libraries are increasingly being used for high-throughput interrogation of animal
venomes. Most previous studies have focused on discovery of new venom toxins, whereas …

Three novel toxins belonging to the scorpion K+ channel-inhibitor family were purified to
homogeneity from the venom of the Chinese scorpion Buthus martensi. They have been …

The intense pain induced by scorpion sting is a frequent clinical manifestation. To date,
there is no established protocol with significant efficacy to alleviate the pain induced by …