Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents

A Di Pino, RA DeFronzo - Endocrine reviews, 2019 - academic.oup.com
Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Diabetes and hypertension: the bad companions

E Ferrannini, WC Cushman - The Lancet, 2012 - thelancet.com
High blood pressure is reported in over two-thirds of patients with type 2 diabetes, and its
development coincides with the development of hyperglycaemia. Many pathophysiological …

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

RA DeFronzo - Diabetologia, 2010 - Springer
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Epicardial fat: definition, measurements and systematic review of main outcomes

AG Bertaso, D Bertol, BB Duncan… - Arquivos brasileiros de …, 2013 - SciELO Brasil
Epicardial fat (EF) is a visceral fat deposit, located between the heart and the pericardium,
which shares many of the pathophysiological properties of other visceral fat deposits, It also …

Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients

J Graessler, D Schwudke, PEH Schwarz, R Herzog… - PloS one, 2009 - journals.plos.org
Background Dyslipoproteinemia, obesity and insulin resistance are integrative constituents
of the metabolic syndrome and are major risk factors for hypertension. The objective of this …

The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease

DM Ouwens, H Sell, S Greulich… - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Fat depots around the heart and vasculature‐Definitions‐Epicardial adipose
tissue‐Perivascular adipose tissue‐Pericardial adipose tissue• Physiological function of …

Impaired myocardial radial function in asymptomatic patients with type 2 diabetes mellitus: a speckle-tracking imaging study

L Ernande, ER Rietzschel, C Bergerot… - Journal of the American …, 2010 - Elsevier
BACKGROUND: Diabetic cardiomyopathy has been characterized by an early impairment of
left ventricular (LV) longitudinal function as opposed to preserved LV radial function …

Ectopic fat and cardiovascular disease: what is the link?

A Gastaldelli, G Basta - Nutrition, Metabolism and cardiovascular diseases, 2010 - Elsevier
AIM: of this paper is to review the recent literature on the relationship between ectopic fat
accumulation and cardiovascular disease. DATA SYNTHESIS: Ectopic fat is an important …

Pericardial rather than epicardial fat is a cardiometabolic risk marker: an MRI vs echo study

R Sicari, AM Sironi, R Petz, F Frassi… - Journal of the American …, 2011 - Elsevier
BACKGROUND: Several studies using echocardiography identified epicardial adipose
tissue (EPI) as an important cardiometabolic risk marker. However, validation compared with …

Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels: potential targets for an efficient preventive …

L Lukic, NM Lalic, N Rajkovic, A Jotic, K Lalic… - International journal of …, 2014 - mdpi.com
Increased body weight as well as type 2 diabetes (T2D) are found to be associated with
increased incidence of hypertension, although the mechanisms facilitating hypertension in …