Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
Developments in scalable strategies for detecting early markers of cognitive decline
Effective strategies for early detection of cognitive decline, if deployed on a large scale,
would have individual and societal benefits. However, current detection methods are …
would have individual and societal benefits. However, current detection methods are …
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease
Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …
Comparing the aggregation free energy landscapes of amyloid beta (1–42) and amyloid beta (1–40)
Using a predictive coarse-grained protein force field, we compute and compare the free
energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein …
energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein …
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
GA Braun, AJ Dear, K Sanagavarapu, H Zetterberg… - Chemical …, 2022 - pubs.rsc.org
The pathology of Alzheimer's disease is connected to the aggregation of β-amyloid (Aβ)
peptide, which in vivo exists as a number of length-variants. Truncations and extensions are …
peptide, which in vivo exists as a number of length-variants. Truncations and extensions are …
The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status
W Gulisano, M Melone, DDL Puma, MR Tropea… - Neurobiology of …, 2018 - Elsevier
The increase of oligomeric amyloid-beta (oAβ) has been related to synaptic dysfunction,
thought to be the earliest event in Alzheimer's disease pathophysiology. Conversely, the …
thought to be the earliest event in Alzheimer's disease pathophysiology. Conversely, the …
Capping of Aβ42 oligomers by small molecule inhibitors
Z Fu, D Aucoin, M Ahmed, M Ziliox… - Biochemistry, 2014 - ACS Publications
Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the
amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be …
amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be …
Alzheimer's disease “non-amyloidogenic” p3 peptide revisited: A case for amyloid-α
Amyloid-β (Aβ) is an intrinsically disordered peptide thought to play an important role in
Alzheimer's disease (AD). It has been the target of most AD therapeutic efforts, which have …
Alzheimer's disease (AD). It has been the target of most AD therapeutic efforts, which have …
Emerging roles of N-and C-terminally truncated Aβ species in Alzheimer's disease
Introduction: Alzheimer's disease (AD) is characterized by a cerebral accumulation and
aggregation of amyloid-β (Aβ) peptides, which mainly accumulate in the form of extracellular …
aggregation of amyloid-β (Aβ) peptides, which mainly accumulate in the form of extracellular …
Intracerebral seeding of amyloid-β and tau pathology in mice: Factors underlying prion-like spreading and comparisons with α-synuclein
Alzheimer's disease (AD) is characterized neuropathologically by progressive
neurodegeneration and by the presence of amyloid plaques and neurofibrillary tangles …
neurodegeneration and by the presence of amyloid plaques and neurofibrillary tangles …