Targeted liposomal drug delivery: a nanoscience and biophysical perspective

Y Liu, KMC Bravo, J Liu - Nanoscale horizons, 2021 - pubs.rsc.org
Liposomes are a unique platform for drug delivery, and a number of liposomal formulations
have already been commercialized. Doxil is a representative example, which uses …

[HTML][HTML] Liposomal drug delivery systems and anticancer drugs

TOB Olusanya, RR Haj Ahmad, DM Ibegbu, JR Smith… - Molecules, 2018 - mdpi.com
Cancer is a life-threatening disease contributing to~ 3.4 million deaths worldwide. There are
various causes of cancer, such as smoking, being overweight or obese, intake of processed …

An NIR Discrete Metallacycle constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for imaging‐guided cancer Radio‐chemotherapy

Y Ding, Z Tong, L Jin, B Ye, J Zhou, Z Sun… - Advanced …, 2022 - Wiley Online Library
To promote the clinical theranostic performances of platinum‐based anticancer drugs,
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …

Engineering poly (ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery

Y Tian, Z Gao, N Wang, M Hu, Y Ju, Q Li… - Journal of the …, 2022 - ACS Publications
Surface modification with poly (ethylene glycol)(PEGylation) is an effective strategy to
improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced Science, 2021 - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

[HTML][HTML] Recent advances in targeted drug delivery strategy for enhancing oncotherapy

J Li, Q Wang, G Xia, N Adilijiang, Y Li, Z Hou, Z Fan… - Pharmaceutics, 2023 - mdpi.com
Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately
deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile …

Membrane wrapping efficiency of elastic nanoparticles during endocytosis: size and shape matter

Z Shen, H Ye, X Yi, Y Li - ACS nano, 2018 - ACS Publications
Using coarse-grained molecular dynamics simulations, we systematically investigate the
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …

Digesting a path forward: the utility of collagenase tumor treatment for improved drug delivery

A Dolor, FC Szoka Jr - Molecular pharmaceutics, 2018 - ACS Publications
Collagen and hyaluronan are the most abundant components of the extracellular matrix
(ECM) and their overexpression in tumors is linked to increased tumor growth and …

Probing the Effect of Rigidity on the Cellular Uptake of Core‐Shell Nanoparticles: Stiffness Effects are Size Dependent

P Gurnani, C Sanchez‐Cano, H Xandri‐Monje… - Small, 2022 - Wiley Online Library
Nanoparticles are well established vectors for the delivery of a wide range of biomedically
relevant cargoes. Numerous studies have investigated the impact of size, shape, charge …

Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates …

G Obaid, S Bano, S Mallidi, M Broekgaarden… - Nano …, 2019 - ACS Publications
Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC),
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …