Background No published meta-analyses have assessed efficacy and effectiveness of
licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to …

In spite of current influenza vaccines being immunogenic, evolution of the influenza virus
can reduce efficacy and so influenza remains a major threat to public health. One approach …

METHODS: In February 2019, we surveyed families with children using the largest online
panel generating representative US samples. After weighting, we assessed hesitancy using …

This report updates the 2018–19 recommendations of the Advisory Committee on
Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the …

This report updates the 2015–16 recommendations of the Advisory Committee on
Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines (Grohskopf …

Background The A (H1N1) pdm09 virus strain used in the live attenuated influenza vaccine
was changed for the 2015–2016 influenza season because of its lack of effectiveness in …

Introduction: Studies in the 1970s and 1980s signaled concern that repeated influenza
vaccination could affect vaccine protection. The antigenic distance hypothesis provided a …

Objective The test-negative design has emerged in recent years as the preferred method for
estimating influenza vaccine effectiveness (VE) in observational studies. However, the …

We introduce the antibody landscape, a method for the quantitative analysis of antibody-
mediated immunity to antigenically variable pathogens, achieved by accounting for …

The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic
mismatch, but even when the match appears good, effectiveness can be surprisingly low …