Stem cell factor receptor/c-Kit: from basic science to clinical implications
J Lennartsson, L Rönnstrand - Physiological reviews, 2012 - journals.physiology.org
Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …
Development, migration, and survival of mast cells
Y Okayama, T Kawakami - Immunologic research, 2006 - Springer
Mast cells play a pivotal role in immediate hypersensitivity and chronic allergic reactions that
can contribute to asthma, atopic dermatitis, and other allergic diseases. Because mast cell …
can contribute to asthma, atopic dermatitis, and other allergic diseases. Because mast cell …
[HTML][HTML] Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
GG McGill, M Horstmann, HR Widlund, J Du… - Cell, 2002 - cell.com
Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in …
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in …
The human mast cell: an overview
G Krishnaswamy, O Ajitawi, DS Chi - Mast Cells: Methods and Protocols, 2005 - Springer
Mast cells are fascinating, multifunctional, tissue-dwelling cells that have been traditionally
associated with the allergic response. However, recent studies suggest these cells may be …
associated with the allergic response. However, recent studies suggest these cells may be …
Recent advances in the understanding of mastocytosis: the role of KIT mutations*
Mastocytosis is a heterogeneous disorder characterised by the expansion and accumulation
of mast cells in different organs and tissues. Mast cell physiology is closely dependent on …
of mast cells in different organs and tissues. Mast cell physiology is closely dependent on …
The human mast cell
G Krishnaswamy, O Ajitawi, DS Chi - Mast Cells, 2001 - Springer
Mast cells are fascinating, multifunctional, tissue-dwelling cells that have been traditionally
associated with the allergic response. However, recent studies suggest these cells may be …
associated with the allergic response. However, recent studies suggest these cells may be …
Th17 CD4+ T-cell as a preferential target for HIV reservoirs
C Renault, N Veyrenche, F Mennechet… - Frontiers in …, 2022 - frontiersin.org
Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against
bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly …
bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly …
Tyrosine kinase inhibitors in the treatment of systemic mastocytosis
C Ustun, DL DeRemer, C Akin - Leukemia research, 2011 - Elsevier
Systemic mastocytosis (SM) is a heterogeneous disease, vast majority of these patients
have a gain of function mutation in the gene encoding the tyrosine kinase KIT (KITD816V). A …
have a gain of function mutation in the gene encoding the tyrosine kinase KIT (KITD816V). A …
Expression of Ki67, BCL-2, and COX-2 in canine cutaneous mast cell tumors: association with grading and prognosis
M Vascellari, M Giantin, K Capello… - Veterinary …, 2013 - journals.sagepub.com
The expression of Ki67, BCL-2, and COX-2 was investigated in 53 canine cutaneous mast
cell tumors (MCTs) by immunohistochemistry and quantitative real time polymerase chain …
cell tumors (MCTs) by immunohistochemistry and quantitative real time polymerase chain …
Stat5 expression is critical for mast cell development and survival
CP Shelburne, ME McCoy, R Piekorz, V Sexl, KH Roh… - Blood, 2003 - ashpublications.org
Abstract Interleukin-3 (IL-3) and stem cell factor (SCF) are important mast cell growth and
differentiation factors. Since both cytokines activate the transcription factor signal transducer …
differentiation factors. Since both cytokines activate the transcription factor signal transducer …